How are neuronal processing delays compensated in primary visual cortex? How are different parameters multiplexed and stimulus traces created at early steps of cortical processing? How plastic is the functional layout of this area and how are natural scenes represented across populations of neurons? I will address these questions from the viewpoint of wide-field optical imaging, a recording method that captures cortical activity at mesoscopic scale. In combination with classical (TMS) and modern perturbation methods (here serotonergic modulation via optogenetics) I will outline further ongoing research directions of our lab that exploit optical imaging technologies to reveal the complexity of visual processing dependent on brain state and behavioral context.
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